Zincfingernuclease

- Zinc finger nucleases (ZFNs). These are based on zinc finger proteins, a family of naturally occurring transcription factors, fused on an endonuclease Fok3.

由 DE Paschon 著作 · 2019 · 被引用 115 次 — Here we develop new ZFN architectures for this purpose via two distinct approaches. First, we adapt a cleavage-based bacterial selection system ...

由 RM Gupta 著作 · 2014 · 被引用 631 次 — Zinc finger nucleases (ZFNs) are increasingly being used in academia and industrial research for a variety of purposes ranging from the ...

由 FD Urnov 著作 · 2010 · 被引用 3032 次 — Zinc finger nucleases (ZFNs) are versatile tools for making precise modifications to genomes, and their use is now established in a range of model systems.

由 D Carroll 著作 · 2011 · 被引用 1340 次 — Zinc-finger nucleases (ZFNs) are targetable DNA cleavage reagents that have been adopted as gene-targeting tools. ZFN-induced double-strand breaks are ...

Zinc Finger Nucleases (ZFNs) were the first widely used programmable DNA binding protein system.11 ZFNs are comprised of a chain of zinc finger proteins fused ...

Zinc-finger nucleases (ZFNs) are artificial restriction enzymes generated by fusing a zinc finger DNA-binding domain to a DNA-cleavage domain.

An improved zinc-finger nuclease architecture for highly specific genome editing. ... 延伸閱讀 編輯. Mandell JG, Barbas CF. Zinc Finger Tools: custom DNA-binding ...